Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double-blind, placebo-controlled trial

Atefeh Zeinoddini 1, Maryam Sorayani, Elmira Hassanzadeh, Mohammad Arbabi, Mehdi Farokhnia, Samrand Salimi, Ali Ghaleiha, Shahin Akhondzadeh PMID: 25620378 DOI: 10.1002/da.22340 Abstract Background: The antidepressive effect of pioglitazone has been noted in patients with major depressive disorder in absence of metabolic syndrome. This study was conducted to evaluate the safety and efficacy of pioglitazone in patients with bipolar depression without concomitant metabolic syndrome or diabetes. Method: Forty-eight […]

Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ‎with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study

Mandana Nojoumi 1, Padideh Ghaeli 2, Samrand Salimi 3, Ali Sharifi 4, Firoozeh Raisi 5 PMID: 27928252 PMCID: PMC5139955 Free PMC article Abstract Objective: Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients […]

Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trial

Ladan Kashani 1, Sophia Esalatmanesh 2, Farzaneh Eftekhari 3, Samrand Salimi 3, Tahereh Foroughifar 3, Farnaz Etesam 2, Hamideh Safiaghdam 2, Ehsan Moazen-Zadeh 2, Shahin Akhondzadeh 4 PMID: 29332222 DOI: 10.1007/s00404-018-4655-2 Abstract Purpose: Due to concerns regarding the side effects of hormone therapy, many studies have focused on the development of non-hormonal agents for treatment of hot flashes. The aim of this study was to evaluate the efficacy and safety of saffron (stigma of Crocus […]

Citicoline Combination Therapy for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

Mahtab Roohi-Azizi 1, Somaye Arabzadeh, Meysam Amidfar, Samrand Salimi, Mohammad Reza Zarindast, Ali Talaei, Shahin Akhondzadeh PMID: 28085707 DOI: 10.1097/WNF.0000000000000185 Abstract Objective: Residual symptoms of major depressive disorder are a source of long-term morbidity. New therapeutic strategies are required to alleviate this morbidity and enhance patient quality of life. Citicoline has been used for vascular accidents and has been effective in cognitive rehabilitation. It has […]

Is self-immolation a distinct method for suicide? A comparison of Iranian patients attempting suicide by self-immolation and by poisoning

Leeba Rezaie 1, Habibolah Khazaie, Akram Soleimani, David C Schwebel PMID: 20708844 DOI: 10.1016/j.burns.2010.07.003 Abstract Objective: Patients who attempted suicide by self-immolation were compared to patients who attempted suicide by poisoning to identify features that might discriminate risk of self-immolation from other suicide methods. Methods: Consecutive referrals for attempted suicide were recruited over a 4-month period (June-September 2008) from Kermanshah Imam Khomeini Hospital, […]

Insomnia treatment by olanzapine. Is sleep state misperception a psychotic disorder?

Habibolah Khazaie 1, Leeba Rezaie, Masoud Tahmasian, David C Schwebel PMID: 20672499 Abstract Offering a new perspective on sleep state misperception, we discuss a patient who presented with sleep state misperception and was ultimately diagnosed with delusional disorder. A 60-year-old woman with chief complaints of insomnia, agitation, and suicidal ideation, was admitted to an inpatient psychiatric ward. Based on information […]

Relationship between Sleep Problems and Self-Injury: A Systematic Review

Habibolah Khazaie 1, Ali Zakiei 1, William Vaughn McCall 2, Khadijeh Noori 1, Masoumeh Rostampour 1, Dena Sadeghi Bahmani 1 3 4 5, Serge Brand 1 3 5 6 7 PMID: 32991212 DOI: 10.1080/15402002.2020.1822360 Abstract Objective/Background: Previous studies suggested that sleep problems were related to non-suicidal self-injury. The current systematic review investigated more thoroughly this relationship.Methods: PubMED and Embase databases were searched. The keywords were “self-injury” OR “self-harm” OR “non-suicidal self-injury” OR “self-injurious behavior” OR “self-destructive behavior” OR “self-mutilation” […]

Treatment of depression in type 2 diabetes with Fluoxetine or Citalopram?

Habibolah Khazaie 1, Mehrali Rahimi, Faeze Tatari, Mansour Rezaei, Farid Najafi, Masoud Tahmasian PMID: 21206443 Abstract Objective: Comparing the antidepressant effects of Citalopram with Fluoxetine and their effect on glycemic control in diabetic patients. Methods: Forty patients attending the Diabetes Research Center in Kermanshah University of Medical Sciences, Kermanshah, Iran from September 2006 to October 2007 with type II diabetes and suffering from major […]

A systematic review of personality temperament models related to somatoform disorder with main focus on meta-analysis of Cloninger’s theory components

Farzin Rezaei 1, Azad Hemmati 2, Khaled Rahmani 3, Saeid Komasi 1 4 PMID: 33678825 PMCID: PMC7909032 DOI: 10.4103/psychiatry.IndianJPsychiatry_345_20 Free PMC article Abstract The systematic review aims to identify four personality temperament models related to somatoform disorder with the main focus on the meta-analysis of temperaments and characters in Cloninger’s theory. The literature search was performed on PubMed (Medline), Scopus, Web of Science, Cochrane, and ProQuest […]

Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial

Areoo Samaei 1, Kamyar Moradi 1, Sayna Bagheri 1, Amir Ashraf-Ganjouei 1, Rosa Alikhani 2, Seiedeh Bentolhoda Mousavi 2, Farzin Rezaei 3, Shahin Akhondzadeh 1 PMID: 33372679 PMCID: PMC7770519 DOI: 10.1093/ijnp/pyaa006 Free PMC article Abstract Background: Patients with schizophrenia can generally manifest a broad variety of primary negative symptoms. The current study aimed to assess the efficacy and tolerability of resveratrol add-on therapy in the treatment of negative symptoms in patients with stable schizophrenia. […]

Vortioxetine as adjunctive therapy to risperidone for treatment of patients with chronic schizophrenia: A randomised, double-blind, placebo-controlled clinical trial

Ehsan Moazen-Zadeh 1 2, Samaneh Bayanati 1, Kimia Ziafat 1 2, Farzin Rezaei 3, Bita Mesgarpour 4, Shahin Akhondzadeh 1 PMID: 32122230 DOI: 10.1177/0269881120909416 Abstract Introduction and objectives: Vortioxetine, a novel antidepressant, may be an interesting candidate for adjunctive therapy of schizophrenia. Our primary objective was to investigate the effect of vortioxetine on negative symptoms, with the assessment of positive, general psychopathology and total symptoms as our secondary goal. Methods: This was […]

Efficacy of melatonin as an adjunct in the treatment of acute mania: a double-blind and placebo-controlled trial

Hossein Sanjari Moghaddam 1, Soya Bahmani 1, Samaneh Bayanati 1, Mahsa Mahdavinasa 1, Farzin Rezaei 2, Shahin Akhondzadeh 1 PMID: 31743233 DOI: 10.1097/YIC.0000000000000298 Abstract This is a double-blind, placebo-controlled, parallel-grouped clinical trial, which was designed to investigate the potential effects of melatonin add-on treatment with lithium and risperidone on acute manic episodes in patients with bipolar disorder (BD). A total of 54 patients were included and randomly assigned […]

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